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Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer’s and cat allergy

Abstract:

Monoclonal antibodies are widely used to treat non-infectious conditions but are costly. Vaccines could offer a cost-effective alternative but have been limited by sub-optimal T-cell stimulation and/or weak vaccine responses in recipients, for example, in elderly patients. We have previously shown that the repetitive structure of virus-like-particles (VLPs) can effectively bypass self-tolerance in therapeutic vaccines. Their efficacy could be increased even further by the incorporation of an ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41541-017-0030-8

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More from this funder
Name:
Swiss Kommission für Technologie und Innovation
Funding agency for:
Bachmann, M
Grant:
15320.1 PFLS-LS
More from this funder
Name:
Medical Research Council
Funding agency for:
El-Turabi, A
Bachmann, M
Grant:
MC_PC_13073
15320.1 PFLS-LS
More from this funder
Name:
Wellcome Trust
Grant:
093305/Z/10/Z
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Publisher:
Nature Publishing Group
Journal:
npj Vaccines More from this journal
Volume:
2
Issue:
30
Pages:
1-13
Publication date:
2017-10-23
Acceptance date:
2017-09-15
DOI:
ISSN:
2059-0105
Keywords:
Pubs id:
pubs:738899
UUID:
uuid:f8fe9093-53c2-45e1-956c-dce16b87fd01
Local pid:
pubs:738899
Source identifiers:
738899
Deposit date:
2017-10-27

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