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Journal article

Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer’s and cat allergy

Abstract:

Monoclonal antibodies are widely used to treat non-infectious conditions but are costly. Vaccines could offer a cost-effective alternative but have been limited by sub-optimal T-cell stimulation and/or weak vaccine responses in recipients, for example, in elderly patients. We have previously shown that the repetitive structure of virus-like-particles (VLPs) can effectively bypass self-tolerance in therapeutic vaccines. Their efficacy could be increased even further by the incorporation of an ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41541-017-0030-8

Authors


Zeltins, A More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; CCMP
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Funding agency for:
El-Turabi, A
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Funding agency for:
Bachmann, M
Publisher:
Nature Publishing Group Publisher's website
Journal:
npj Vaccines Journal website
Volume:
2
Issue:
30
Pages:
1-13
Publication date:
2017-10-23
Acceptance date:
2017-09-15
DOI:
ISSN:
2059-0105
Pubs id:
pubs:738899
URN:
uri:f8fe9093-53c2-45e1-956c-dce16b87fd01
UUID:
uuid:f8fe9093-53c2-45e1-956c-dce16b87fd01
Local pid:
pubs:738899
Keywords:

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