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Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer.

Abstract:

BACKGROUND: Vascular endothelial cell growth factor (VEGF) acts by phosphorylating specific tyrosine kinase receptors on endothelial cell membrane promoting angiogenesis. The study of the activation status of VEGF receptors in human malignancies has recently become feasible by means of specific monoclonal antibodies recognising the phosphorylated form of these receptors. MATERIALS AND METHODS: In the current study, we investigate the expression of the phosphorylated VEGFR2/KDR receptor in nor...

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Publication status:
Published

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Journal:
European journal of clinical investigation More from this journal
Volume:
37
Issue:
11
Pages:
878-886
Publication date:
2007-11-01
DOI:
EISSN:
1365-2362
ISSN:
0014-2972

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