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Journal article

Discovery of the first selective, nonpeptidic orexin 2 receptor agonists

Abstract:
In this issue, Nagase and colleagues report the discovery of the first selective nonpeptidic orexin 2 receptor (OX2R) agonists. The discovery of these OX2R selective agonists opens up new avenues for therapies related to the activation of the orexin system, especially with respect to the treatment of sleep disorders such as narcolepsy.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jmedchem.5b01394

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
American Chemical Society
Journal:
Journal of Medicinal Chemistry More from this journal
Volume:
58
Issue:
20
Pages:
7928-7930
Publication date:
2015-09-16
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
Language:
English
Pubs id:
pubs:574585
UUID:
uuid:f8f268c7-3715-4503-b634-8c2fe481d526
Local pid:
pubs:574585
Source identifiers:
574585
Deposit date:
2016-03-14

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