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Do the endocrine and subjective effects of d-fenfluramine predict response to selective serotonin reuptake inhibitors?

Abstract:

Thirty drug-free depressed patients underwent double-blind, placebo-controlled, neuroendocrine testing with the serotonin (5-HT) releasing agent d-fenfluramine prior to receiving treatment with a selective serotonin reuptake inhibitor (SSRI) for 8 weeks. Compared to placebo, d-fenfluramine significantly elevated plasma levels of prolactin and cortisol, increased subjective visual analogue ratings of "light headed" and decreased ratings of "desire to eat". Of the 30 patients studied, 17 respon...

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Publication status:
Published

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Journal:
International clinical psychopharmacology More from this journal
Volume:
10
Issue:
4
Pages:
215-220
Publication date:
1995-11-01
DOI:
EISSN:
1473-5857
ISSN:
0268-1315
Language:
English
Keywords:
Pubs id:
pubs:185981
UUID:
uuid:f8eb92b9-b331-413f-b10e-2fe615e2435c
Local pid:
pubs:185981
Source identifiers:
185981
Deposit date:
2012-12-19

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