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Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

Abstract:

The membrane-associated matrix metalloproteinase-14, MT1-MMP, has been implicated in pericellular proteolysis with an important role in cellular invasion of collagenous tissues. It is substantially upregulated in various cancers and rheumatoid arthritis, and has been considered as a potential therapeutic target. Here, we report the identification of antibody fragments to MT1-MMP that potently and specifically inhibit its cell surface functions. Lead antibody clones displayed inhibitory activi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-3259-3096
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Name:
Versus Arthritis
Grant:
19797
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Name:
Medical Research Council
Grant:
G0802007
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Name:
Arthritis Research UK
Grant:
19797
Publisher:
Impact Journals
Journal:
Oncotarget More from this journal
Volume:
7
Issue:
13
Pages:
16773-16792
Publication date:
2016-02-27
Acceptance date:
2016-01-23
DOI:
ISSN:
1949-2553
Pmid:
26934448
Language:
English
Keywords:
Pubs id:
pubs:609111
UUID:
uuid:f8e763eb-a09e-4f03-8aea-4940d617f52b
Local pid:
pubs:609111
Source identifiers:
609111
Deposit date:
2019-06-26

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