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Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia.

Abstract:

PURPOSE OF REVIEW: Dietary supplementation with folic acid and vitamin B12 lowers blood homocysteine concentrations, but it is not known if this reduces the risk of coronary heart disease and stroke. RECENT FINDINGS: Recent evidence suggests that the maximum reduction in plasma homocysteine concentrations is obtained with 0.8 mg of folic acid and doses of 0.2 mg and 0.4 mg of folic acid are associated with about 60 and 90%, respectively, of this maximal effect. Among 12 large trials (involvin...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Sherliker, P More by this author
Armitage, J More by this author
Journal:
Current opinion in clinical nutrition and metabolic care
Volume:
10
Issue:
1
Pages:
32-39
Publication date:
2007-01-05
DOI:
EISSN:
1473-6519
ISSN:
1363-1950
URN:
uuid:f8e3fa56-c449-4b2d-a788-2bba1260af3c
Source identifiers:
33689
Local pid:
pubs:33689

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