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Journal article

Neisseria meningitidis native outer membrane vesicles containing different lipopolysaccharide glycoforms as adjuvants for meningococcal and nonmeningococcal antigens.

Abstract:

We evaluated the adjuvant effect of a modified glycoform of lipopolysaccharide (LPS) (LgtB-LpxL1) compared to that of the nonmodified glycoform Lpxl1 serogroup B meningococcal H44/76 native outer membrane vesicles (nOMVs) on immune responses to vaccination with the recombinant meningococcal protein, rPorA, tetanus toxoid, or meningococcal serogroup C capsular polysaccharide. We used LgtB-LpxL1 LPS because the disruption of the lgtB gene, which results in the exposure of N-acetylglucosamine-ga...

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Publication status:
Published

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Publisher copy:
10.1128/cvi.00561-13

Authors


Nagaputra, JC More by this author
Rollier, CS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
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Journal:
Clinical and vaccine immunology : CVI
Volume:
21
Issue:
2
Pages:
234-242
Publication date:
2014-02-05
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
URN:
uuid:f8e3330f-1970-4b7c-a048-381bf6b9cca7
Source identifiers:
444287
Local pid:
pubs:444287

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