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Journal article

Neisseria meningitidis native outer membrane vesicles containing different lipopolysaccharide glycoforms as adjuvants for meningococcal and nonmeningococcal antigens.

Abstract:

We evaluated the adjuvant effect of a modified glycoform of lipopolysaccharide (LPS) (LgtB-LpxL1) compared to that of the nonmodified glycoform Lpxl1 serogroup B meningococcal H44/76 native outer membrane vesicles (nOMVs) on immune responses to vaccination with the recombinant meningococcal protein, rPorA, tetanus toxoid, or meningococcal serogroup C capsular polysaccharide. We used LgtB-LpxL1 LPS because the disruption of the lgtB gene, which results in the exposure of N-acetylglucosamine-ga...

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Publication status:
Published

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Publisher copy:
10.1128/cvi.00561-13

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
Journal:
Clinical and vaccine immunology : CVI More from this journal
Volume:
21
Issue:
2
Pages:
234-242
Publication date:
2014-02-01
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
Language:
English
Keywords:
Pubs id:
pubs:444287
UUID:
uuid:f8e3330f-1970-4b7c-a048-381bf6b9cca7
Local pid:
pubs:444287
Source identifiers:
444287
Deposit date:
2014-02-08

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