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Thesis

Dissecting the function of the Leishmania flagellum in a CRISPR-Cas9 knockout screen

Abstract:

Eukaryotic cilia and flagella are conserved organelles with specialized structures and functions. Cilia and flagella can be well studied in parasites of the genus Leishmania, which possess at different stages in their life cycle either a motile 9 + 2 or immotile 9 + 0 flagellum. Much remains unknown about Leishmania-specific flagellar biology, for example whether flagellar motility is required throughout the Leishmania life cycle. More fundamentally, it is still not fully known how flagell...

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Division:
MSD
Department:
Pathology Dunn School
Department:
University of Oxford, Sir William Dunn School of Pathology
Role:
Author

Contributors

Department:
University of Oxford, Sir William Dunn School of Pathology
Role:
Supervisor
Department:
University of Oxford, Sir William Dunn School of Pathology
Role:
Examiner
Department:
University of Glasgow
Role:
Examiner
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Name:
Medical Research Council
Grant:
15/16_MSD_836338
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:f8e1fdda-1968-4561-ae3f-a00d5c84ad79
Deposit date:
2020-02-03

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