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Linear IgA disease: a report of two dermal binding sera which recognize a pepsin-sensitive epitope (?NC-1 domain) of collagen type VII.

Abstract:

Linear IgA disease is a subepidermal blistering disease characterized by IgA autoantibody deposition at the basement membrane zone of skin and mucosa. The antigens targeted in linear IgA disease have been defined by their molecular weight and localization. It has been proposed that a minority of linear IgA disease sera that bind to the dermal aspect of salt-split skin target collagen type VII. We have identified two patients with linear IgA disease using dermal binding IgA autoantibodies on s...

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Publication status:
Published

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Host title:
The British journal of dermatology
Volume:
137
Issue:
4
Pages:
526-533
Publication date:
1997-10-01
Event location:
ENGLAND
DOI:
EISSN:
1365-2133
ISSN:
0007-0963

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