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Vulnerability to Alzheimer's pathology in neocortex: the roles of plasticity and columnar organization.

Abstract:

Two principal findings in the Pearson et al. paper are commented on here. The first is the regional selectivity within the cerebrum of neurofibrillary tangle (NFT) formation in Alzheimer's disease (AD) which targets association cortex and the primary olfactory cortex alone among regions of primary sensory cortex. The second finding is the clustering of NFT in columns of supra- and infra-granular layers of association cortex. We review recent evidence confirming these findings and comment on t...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Chance, SA More by this author
Journal:
Journal of Alzheimer's disease : JAD
Volume:
9
Issue:
3 Suppl
Pages:
79-89
Publication date:
2006
EISSN:
1875-8908
ISSN:
1387-2877
URN:
uuid:f8dc7be9-713a-48a3-b4da-06c2a8773948
Source identifiers:
266144
Local pid:
pubs:266144

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