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The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

Abstract:

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. ...

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Publication status:
Published

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Publisher copy:
10.1126/science.1112631

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Journal:
Science (New York, N.Y.)
Volume:
309
Issue:
5733
Pages:
409-415
Publication date:
2005-07-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:f8da9181-f788-4dbf-97a4-e8e5fc68d412
Source identifiers:
15547
Local pid:
pubs:15547

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