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The ACE gene and Alzheimer's disease susceptibility.

Abstract:

A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged >73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While ...

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Publication status:
Published

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Publisher copy:
10.1136/jmg.37.9.695

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Journal:
Journal of medical genetics More from this journal
Volume:
37
Issue:
9
Pages:
695-697
Publication date:
2000-09-01
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
Language:
English
Keywords:
Pubs id:
pubs:242243
UUID:
uuid:f8d36694-2d1a-4dc1-9344-95d8a8aaae09
Local pid:
pubs:242243
Source identifiers:
242243
Deposit date:
2012-12-19

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