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Journal article

Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.

Abstract:

Strong CD4(+) and CD8(+) T cell responses are considered important immune components for controlling HIV infection, and their priming may be central to an effective HIV vaccine. We describe in this study an approach by which multiple CD4(+) and CD8(+) T cell epitopes are processed and presented from an exogenously added HIV-1 Gag-p24 peptide of 32 aa complexed to heat shock protein (HSP) gp96. CD8(+) T cell recognition of the HSP/peptide complex, but not the peptide alone, was inhibited by br...

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Publisher copy:
10.4049/jimmunol.173.3.1987

Authors


SenGupta, D More by this author
Norris, PJ More by this author
Suscovich, TJ More by this author
Hassan-Zahraee, M More by this author
Moffett, HF More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
173
Issue:
3
Pages:
1987-1993
Publication date:
2004-08-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:f8cdd5e3-340c-4eb7-aafc-89d426b374cc
Source identifiers:
191117
Local pid:
pubs:191117

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