Journal article icon

Journal article

The functional organization of mitochondrial genomes in human cells.

Abstract:

BACKGROUND: We analyzed the organization and function of mitochondrial DNA in a stable human cell line (ECV304, which is also known as T-24) containing mitochondria tagged with the yellow fluorescent protein. RESULTS: Mitochondrial DNA is organized in approximately 475 discrete foci containing 6-10 genomes. These foci (nucleoids) are tethered directly or indirectly through mitochondrial membranes to kinesin, marked by KIF5B, and microtubules in the surrounding cytoplasm. In living cells, foc...

Expand abstract

Actions


Access Document


Publisher copy:
10.1186/1741-7007-2-9

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
BMC biology More from this journal
Volume:
2
Pages:
9
Publication date:
2004-01-01
DOI:
EISSN:
1741-7007
Language:
English
Keywords:
Pubs id:
pubs:1696
UUID:
uuid:f8cb1972-6d65-44f6-87f2-4b755d68c2a0
Local pid:
pubs:1696
Source identifiers:
1696
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP