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The functional organization of mitochondrial genomes in human cells.

Abstract:

BACKGROUND: We analyzed the organization and function of mitochondrial DNA in a stable human cell line (ECV304, which is also known as T-24) containing mitochondria tagged with the yellow fluorescent protein. RESULTS: Mitochondrial DNA is organized in approximately 475 discrete foci containing 6-10 genomes. These foci (nucleoids) are tethered directly or indirectly through mitochondrial membranes to kinesin, marked by KIF5B, and microtubules in the surrounding cytoplasm. In living cells, foc...

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Publisher copy:
10.1186/1741-7007-2-9

Authors


Iborra, FJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
BMC biology
Volume:
2
Pages:
9
Publication date:
2004
DOI:
EISSN:
1741-7007
URN:
uuid:f8cb1972-6d65-44f6-87f2-4b755d68c2a0
Source identifiers:
1696
Local pid:
pubs:1696

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