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Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway

Abstract:

The oxygen sensitive prolyl-hydroxylase domain enzymes (PHDs) and the asparagines hydroxylase (FIH, factor inhibiting HIF) regulate the transcriptional activity of HIFs. We assessed the expression of these enzymes in a series of 73 non-small cell lung carcinomas (NSCLC). A direct association of PHDs with FIH and of the PHDs/FIH with HIFs expression was noted. Thirty three of 73 cases had high HIF/PHD expression, predicting intense HIF activity; 19/73 cases had low HIF and high PHD expression ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
Journal:
Cancer Letters More from this journal
Volume:
262
Issue:
1
Pages:
87-93
Publication date:
2008-04-08
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
Language:
English
Keywords:
Pubs id:
pubs:170312
UUID:
uuid:f8c8bc3a-363b-495b-87fe-b4742e4535b3
Local pid:
pubs:170312
Source identifiers:
170312
Deposit date:
2012-12-19

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