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An evolutionary model to predict the frequency of antibiotic resistance under seasonal antibiotic use, and an application to Streptococcus pneumoniae.

Abstract:

The frequency of resistance to antibiotics in Streptococcus pneumoniae has been stable over recent decades. For example, penicillin non-susceptibility in Europe has fluctuated between 12% and 16% without any major time trend. In spite of long-term stability, resistance fluctuates over short time scales, presumably in part due to seasonal fluctuations in antibiotic prescriptions. Here, we develop a model that describes the evolution of antibiotic resistance under selection by multiple antibiot...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rspb.2017.0679

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
National Institutes of Health
Grant:
U01GM110721
More from this funder
Name:
Marie Sklodowska-Curie Individual Fellowship
Grant:
657768
Publisher:
Royal Society
Journal:
Proceedings of the Royal Society B: Biological Sciences More from this journal
Volume:
284
Issue:
1855
Pages:
20170679
Publication date:
2017-05-01
Acceptance date:
2017-05-02
DOI:
ISSN:
1471-2954
Language:
English
Keywords:
Pubs id:
pubs:698370
UUID:
uuid:f8c43cb3-12be-4921-8c05-0c8043803d29
Local pid:
pubs:698370
Source identifiers:
698370
Deposit date:
2017-06-09

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