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Activated T-follicular helper 2 cells are associated with disease activity in IgG4-related sclerosing cholangitis and pancreatitis

Abstract:

Objectives: Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) and autoimmune pancreatitis (AIP) are characterized by an abundance of circulating and tissue IgG4-positive plasma cells. T-follicular helper (Tfh) cells are necessary for B-cell differentiation into plasma cells. We aimed at elucidating the presence and phenotype of Tfh cells and their relationship with disease activity in IgG4-SC/AIP.

Methods: Circulating Tfh-cell subsets were ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Lighaam, LC More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
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Publisher:
Wolters Kluwer Health Publisher's website
Journal:
Clinical and Translational Gastroenterology Journal website
Volume:
10
Issue:
4
Pages:
Article: e00020
Publication date:
2019-04-01
Acceptance date:
2019-01-31
DOI:
ISSN:
2155-384X
Pubs id:
pubs:994765
URN:
uri:f8bdbfa5-397d-42a4-8bba-09dba20a3a80
UUID:
uuid:f8bdbfa5-397d-42a4-8bba-09dba20a3a80
Local pid:
pubs:994765
Language:
English

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