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NEDDylation regulates E2F-1-dependent transcription.

Abstract:

The ubiquitin-like molecule NEDD8 modifies cullin-RING ubiquitin E3 ligases. NEDD8 has been shown to have a few additional substrates, but the extent to which this modification targets non-cullins and the functional significance of such modifications remain unclear. Here, we demonstrate that the cell-cycle-regulating transcription factor E2F-1 is a substrate for NEDD8 post-translational modification. NEDDylation results in decreased E2F-1 stability, lower transcriptional activity and slower c...

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Publication status:
Published

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Publisher copy:
10.1038/embor.2012.113

Authors


Loftus, SJ More by this author
La Thangue, NB More by this author
Journal:
EMBO reports
Volume:
13
Issue:
9
Pages:
811-818
Publication date:
2012-09-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:f8bd0205-f848-4bb2-bc71-91e5eacf9ea1
Source identifiers:
344224
Local pid:
pubs:344224

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