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Journal article

Human innate lymphoid cell subsets possess tissue-type based heterogeneity in phenotype and frequency

Abstract:

Animal models have highlighted the importance of innate lymphoid cells (ILCs) in multiple immune responses. However, technical limitations have hampered adequate characterization of ILCs in humans. Here, we used mass cytometry including a broad range of surface markers and transcription factors to accurately identify and profile ILCs across healthy and inflamed tissue types. High dimensional analysis allowed for clear phenotypic delineation of ILC2 and ILC3 subsets. We were not able to detect...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.immuni.2016.11.005

Authors


More from this funder
Name:
National Institute for Health Research
Funding agency for:
Klenerman, P
Grant:
WT109965MA
More from this funder
Name:
National Cancer Center Singapore
Grant:
NCCSPG-YR2015-JUL-13
More from this funder
Name:
National Medical Research Council, Singapore
Grant:
NMRC/TCR/007-NCC/2013
Publisher:
Elsevier
Journal:
Immunity More from this journal
Volume:
46
Issue:
1
Pages:
148-161
Publication date:
2016-12-13
Acceptance date:
2016-10-25
DOI:
EISSN:
1074-7613
ISSN:
1097-4180
Language:
English
Keywords:
Pubs id:
pubs:666544
UUID:
uuid:f8bbc7e0-ce08-43d1-ac57-75ffe65863ca
Local pid:
pubs:666544
Source identifiers:
666544
Deposit date:
2017-01-20

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