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HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.

Abstract:

For efficient entry into target cells, certain T cell-tropic HIV-1 isolates require both CD4 and the coreceptor CXCR4. However, the molecular interactions among CD4, CXCR4, and the HIV-1 envelope glycoproteins are only now being elucidated. Here we show that the binding of soluble gp120 from one macrophage-tropic and four T cell-tropic viruses to a CD4+, but not to a CD4-, T cell line, decreased the binding of an mAb specific for CXCR4 to its epitope, implying an interaction among gp120, CD4,...

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Publication status:
Published

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Journal:
Journal of Immunology More from this journal
Volume:
159
Issue:
6
Pages:
3000-3008
Publication date:
1997-09-01
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:22965
UUID:
uuid:f8b765f3-5942-4779-aac2-90caac4efd8b
Local pid:
pubs:22965
Source identifiers:
22965
Deposit date:
2012-12-19

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