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Journal article

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.

Abstract:

BACKGROUND: Bradycardic agents are of interest for the treatment of ischemic heart disease and heart failure, as heart rate is an important determinant of myocardial oxygen consumption. OBJECTIVES: The purpose of this study was to investigate the propensity of hydroxychloroquine (HCQ) to cause bradycardia. METHODS: We assessed the effects of HCQ on (1) cardiac beating rate in vitro (mice); (2) the "funny" current (If) in isolated guinea pig sinoatrial node (SAN) myocytes (1, 3, 10 µM); (3) he...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Name:
Royal Society
Funding agency for:
Mirams, G
Grant:
101222/Z/13/Z
More from this funder
Name:
Wellcome Trust
Funding agency for:
Mirams, G
Grant:
101222/Z/13/Z
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Yavari, A
More from this funder
Name:
British Heart Foundation
Funding agency for:
Capel, R
Burton, R
Publisher:
Elsevier
Journal:
Heart rhythm : the official journal of the Heart Rhythm Society More from this journal
Volume:
12
Issue:
10
Pages:
2186-2194
Publication date:
2015-10-01
DOI:
EISSN:
1556-3871
ISSN:
1547-5271
Language:
English
Keywords:
Pubs id:
pubs:525633
UUID:
uuid:f8a7a680-1c07-4794-aee7-48557313bc59
Local pid:
pubs:525633
Source identifiers:
525633
Deposit date:
2015-10-13

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