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Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting.

Abstract:

The copines are a family of C2- and von Willebrand factor A-domain-containing proteins that have been proposed to respond to increases in intracellular calcium by translocating to the plasma membrane. The copines have been reported to interact with a range of cell signalling and cytoskeletal proteins, which may therefore be targeted to the membrane following increases in cellular calcium. However, neither the function of the copines, nor their actual movement to the plasma membrane, has been ...

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Journal:
The FEBS journal
Volume:
277
Issue:
24
Pages:
5174-5189
Publication date:
2010-12-05
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
URN:
uuid:f8a598c6-494e-4c50-a4e0-c86e652ae4b0
Source identifiers:
375609
Local pid:
pubs:375609

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