Journal article icon

Journal article

The Ba2+ block of the ATP-sensitive K+ current of mouse pancreatic beta-cells.

Abstract:

We studied the block of whole-cell ATP-sensitive K+ (KATP) currents in mouse pancreatic beta-cells produced by external Ba2+. Ba2+ produced a time-and voltage-dependent block of KATP currents, both the rate and extent of the block increasing with hyperpolarization. With 5.6 mM [K+]o, the relationship between the steady-state KATP current and [Ba2+]o was fit by the Hill equation with a Kd of 12.5 +/- 2.8 microM at -123 mV and of 0.18 +/- 0.02 mM at -62 mV. The Hill coefficient (n) was close to...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s004240050044

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Pflugers Archiv : European journal of physiology
Volume:
431
Issue:
4
Pages:
625-631
Publication date:
1996-02-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:f8a4f77c-4784-4162-b70e-406d989850ef
Source identifiers:
114195
Local pid:
pubs:114195

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP