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The Ba2+ block of the ATP-sensitive K+ current of mouse pancreatic beta-cells.

Abstract:

We studied the block of whole-cell ATP-sensitive K+ (KATP) currents in mouse pancreatic beta-cells produced by external Ba2+. Ba2+ produced a time-and voltage-dependent block of KATP currents, both the rate and extent of the block increasing with hyperpolarization. With 5.6 mM [K+]o, the relationship between the steady-state KATP current and [Ba2+]o was fit by the Hill equation with a Kd of 12.5 +/- 2.8 microM at -123 mV and of 0.18 +/- 0.02 mM at -62 mV. The Hill coefficient (n) was close to...

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Publication status:
Published

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Publisher copy:
10.1007/s004240050044

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Pflugers Archiv : European journal of physiology More from this journal
Volume:
431
Issue:
4
Pages:
625-631
Publication date:
1996-02-01
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
Language:
English
Keywords:
Pubs id:
pubs:114195
UUID:
uuid:f8a4f77c-4784-4162-b70e-406d989850ef
Local pid:
pubs:114195
Source identifiers:
114195
Deposit date:
2012-12-19

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