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Characterisation of voltage-gated calcium channels and detection of their autoantibodies

Abstract:

The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of impaired neuromuscular transmission. It is associated with small cell lung carcinoma (SCLC) in 60% of patients. There is considerable evidence that the defect in LEMS is caused by autoantibodies to voltage-gated calcium channels (VGCCs) on the nerve terminal.

Two VGCC subtypes were demonstrated in cultured neuronal cell lines by the technique of K+-induced 45Ca2+ influx: one s...

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Institution:
University of Oxford
Division:
MSD
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
1991
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:f8a39d64-6491-45ea-91a3-71f3f969fd07
Local pid:
td:602809776
Source identifiers:
602809776
Deposit date:
2013-10-21

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