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The balance between inactivation and activation of the Na+−K+ pump underlies the triphasic accumulation of extracellular K+ during myocardial ischemia

Abstract:

Ischemia-induced hyperkalemia (accumulation of extracellular K(+)) predisposes the heart to the development of lethal reentrant ventricular arrhythmias. This phenomenon exhibits a triphasic time course and is thought to be mediated by a combination of three mechanisms: 1) increased cellular K(+) efflux, 2) decreased cellular K(+) influx, and 3) shrinkage of the extracellular space. These ischemia-induced electrophysiological changes are driven by an impaired cellular metabolism. However, the ...

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Journal:
Am J Physiol Heart Circ Physiol More from this journal
Volume:
293
Issue:
5
Pages:
3036-45
Publication date:
2007-01-01
UUID:
uuid:f8a1848a-b145-488b-b7b8-8c135fdc3a6c
Local pid:
cs:1503
Deposit date:
2015-03-31

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