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Autophagic activity dictates the cellular response to oncogenic RAS.

Abstract:

RAS is frequently mutated in human cancers and has opposing effects on autophagy and tumorigenesis. Identifying determinants of the cellular responses to RAS is therefore vital in cancer research. Here, we show that autophagic activity dictates the cellular response to oncogenic RAS. N-terminal Apoptosis-stimulating of p53 protein 2 (ASPP2) mediates RAS-induced senescence and inhibits autophagy. Oncogenic RAS-expressing ASPP2((Δ3/Δ3)) mouse embryonic fibroblasts that escape senescence express...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1120193109

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
109
Issue:
33
Pages:
13325-13330
Publication date:
2012-08-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:344159
UUID:
uuid:f89c09d5-2505-4f6b-9947-d275ee9ff516
Local pid:
pubs:344159
Source identifiers:
344159
Deposit date:
2012-12-19

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