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Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase

Abstract:

Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is a collaborative, curated knowledgebase, designed to standardize and aggregate global Mycobacterium tuberculosis complex (MTBC) variant data from whole genome sequencing (WGS) with phenotypic drug susceptibility testing (DST) and clinical data. We developed a unified analysis variant pipeline (UVP) ( https://github.com/CPTR-ReSeqTB/UVP ) to identify variants and assign lineage from MTBC sequence data. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-5695-3463
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Role:
Author
ORCID:
0000-0002-0463-0101
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Role:
Author
ORCID:
0000-0003-4610-2427
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Name:
European Research Council
Grant:
638553
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Name:
Spanish Ministry of Economics and Competitiveness
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Name:
Natural Sciences and Engineering Research Council of Canada
Publisher:
Nature Publishing Group
Journal:
Scientific Reports More from this journal
Volume:
8
Issue:
1
Pages:
15382
Publication date:
2018-10-18
Acceptance date:
2018-09-11
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
30337678
Language:
English
Keywords:
Pubs id:
pubs:935241
UUID:
uuid:f88eba31-a986-4610-929d-ba428254e9a0
Local pid:
pubs:935241
Source identifiers:
935241
Deposit date:
2018-12-06

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