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Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylas

Abstract:

Human aspartate/asparagine-β-hydroxylase (AspH) is a 2-oxoglutarate (2OG) dependent oxygenase that catalyses the hydroxylation of Asp/Asn-residues of epidermal growth factor-like domains (EGFDs). AspH is reported to be upregulated on the cell surface of invasive cancer cells in a manner distinguishing healthy from cancer cells. We report studies on the effect of small-molecule active pharmaceutical ingredients (APIs) of human cancer therapeutics on the catalytic activity of AspH using a high-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0002-0290-6565
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Name:
Wellcome Trust
Grant:
106244/Z/14/Z
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Name:
Cancer Research UK
Grant:
18245
More from this funder
Name:
Biotechnology and Biological Sciences Research Counc
Grant:
BB/D011523/1
Publisher:
Elsevier
Journal:
Bioorganic and Medicinal Chemistry More from this journal
Volume:
28
Issue:
20
Article number:
115675
Publication date:
2020-08-06
Acceptance date:
2020-07-16
DOI:
ISSN:
0968-0896
Language:
English
Keywords:
Pubs id:
1120551
Local pid:
pubs:1120551
Deposit date:
2020-07-21

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