Journal article icon

Journal article

The nuclear matrix protein CIZ1 facilitates localisation of Xist RNA to the inactive X-chromosome territory

Abstract:

The nuclear matrix protein Cip1-interacting zinc finger protein 1 (CIZ1) promotes DNA replication in association with cyclins, and has been linked with adult and pediatric cancers. Here we show that CIZ1 is highly enriched on the inactive X chromosome (Xi) in mouse and human female cells, and is retained by interaction with the RNAdependent nuclear matrix. CIZ1 is recruited to Xi in response to expression of Xist RNA during the earliest stages of X-inactivation in embryonic stem cells, and is...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1101/gad.295907.117

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Nesterova, T
Grant:
091911
103768
More from this funder
Name:
Genetics Society
Grant:
training funds
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
PhD training scholarships
More from this funder
Name:
University of York
Grant:
priming funds
More from this funder
Name:
Radhika Sreedhar Scholarship
Publisher:
Cold Spring Harbor Laboratory Press
Journal:
Genes and Development More from this journal
Volume:
31
Pages:
1-13
Publication date:
2017-05-01
Acceptance date:
2017-05-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Keywords:
Pubs id:
pubs:696969
UUID:
uuid:f86d7137-e362-4944-ba5b-f7ea0fe63ca5
Local pid:
pubs:696969
Source identifiers:
696969
Deposit date:
2017-05-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP