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The nuclear matrix protein CIZ1 facilitates localisation of Xist RNA to the inactive X-chromosome territory

Abstract:

The nuclear matrix protein Cip1-interacting zinc finger protein 1 (CIZ1) promotes DNA replication in association with cyclins, and has been linked with adult and pediatric cancers. Here we show that CIZ1 is highly enriched on the inactive X chromosome (Xi) in mouse and human female cells, and is retained by interaction with the RNAdependent nuclear matrix. CIZ1 is recruited to Xi in response to expression of Xist RNA during the earliest stages of X-inactivation in embryonic stem cells, and is...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1101/gad.295907.117

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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Funding agency for:
Nesterova, TB
Radhika Sreedhar Scholarship More from this funder
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genes and Development Journal website
Volume:
31
Pages:
1-13
Publication date:
2017-05-05
Acceptance date:
2017-05-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Pubs id:
pubs:696969
URN:
uri:f86d7137-e362-4944-ba5b-f7ea0fe63ca5
UUID:
uuid:f86d7137-e362-4944-ba5b-f7ea0fe63ca5
Local pid:
pubs:696969

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