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Mouse knockout models for HIV-1 restriction factors.

Abstract:

Infection of cells with human immunodeficiency virus 1 (HIV-1) is controlled by restriction factors, host proteins that counteract a variety of steps in the life cycle of this lentivirus. These include SAMHD1, APOBEC3G and tetherin, which block reverse transcription, hypermutate viral DNA and prevent progeny virus release, respectively. These and other HIV-1 restriction factors are conserved and have clear orthologues in the mouse. This review summarises studies in knockout mice lacking HIV-1...

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Publisher copy:
10.1007/s00018-014-1646-8
Journal:
Cellular and molecular life sciences : CMLS More from this journal
Volume:
71
Issue:
19
Pages:
3749-3766
Publication date:
2014-01-01
DOI:
EISSN:
1420-9071
Language:
English
Pubs id:
pubs:491440
UUID:
uuid:f85fea9e-2f5e-4a88-bbc2-14236d16eb42
Local pid:
pubs:491440
Source identifiers:
491440
Deposit date:
2014-12-12

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