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DNA methylation alterations—potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity?

Abstract:

Alterations in the DNA methylation pattern of endometriotic lesions and endometrium of endometriosis patients have been proposed as one potential factor accompanying the endometriosis development. Although many differentially methylated genes have been associated with the pathogenesis of this disease, the overlap between the results of different studies has remained small. Among other potential confounders, the impact of tissue heterogeneity on the outcome of DNA methylation studies should be...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/biolre/ioy067

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Womens & Reproductive Health
Role:
Author
More from this funder
Name:
Horizon 2020
Grant:
691058
More from this funder
Name:
Seventh Framework Programme
Grant:
EU324509
More from this funder
Name:
Estonian Ministry of Education and Research
Publisher:
Oxford University Press
Journal:
Biology of Reproduction More from this journal
Volume:
99
Issue:
2
Pages:
273–282
Publication date:
2018-03-21
Acceptance date:
2018-03-20
DOI:
EISSN:
1529-7268
ISSN:
0006-3363
Pmid:
29796617
Language:
English
Keywords:
Pubs id:
pubs:854533
UUID:
uuid:f85e3ae3-a758-420f-9682-2bd56b846c38
Local pid:
pubs:854533
Source identifiers:
854533
Deposit date:
2018-06-17

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