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Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.

Abstract:

Multiple genetic alterations such as in Ras or EGFR can result in sustained signaling through PI3K. Our previous experiments have shown that resistance to radiation results from PI3K activity in cells in culture. Here we examined whether inhibition of PI3K in vivo would sensitize tumors to radiation. The human bladder cancer cell line T24 has amplified and mutated H-Ras resulting in sustained PI3K activity and phosphorylation of the downstream target of PI3K, Akt. Nude mice bearing T24 tumor ...

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Publication status:
Published

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Authors


Cerniglia, GJ More by this author
Bakanauskas, VJ More by this author
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Journal:
International journal of radiation oncology, biology, physics
Volume:
56
Issue:
3
Pages:
846-853
Publication date:
2003-07-05
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
URN:
uuid:f85073eb-3d3f-440e-a37b-c587c3c962dc
Source identifiers:
118192
Local pid:
pubs:118192

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