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Journal article

Application of single-cell genomics in cancer: promise and challenges.

Abstract:

Recent advances in single-cell genomics are opening up unprecedented opportunities to transform cancer genomics. While bulk tissue genomic analysis across large populations of tumour cells has provided key insights into cancer biology, this approach does not provide the resolution that is critical for understanding the interaction between different genetic events within the cellular hierarchy of the tumour during disease initiation, evolution, relapse and metastasis. Single-cell genomic appro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddv235

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More from this funder
Name:
Oxford NIHR Biomedical Research Centre Programme
Funding agency for:
Mead, A
Grant:
Senior Clinical Fellowship
More from this funder
Name:
Medical Research Council
Funding agency for:
Mead, A
Grant:
Senior Clinical Fellowship
Publisher:
Oxford University Press
Journal:
Human Molecular Genetics More from this journal
Volume:
24
Issue:
R1
Pages:
R74-R84
Publication date:
2015-06-25
Acceptance date:
2015-06-18
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Language:
English
Pubs id:
pubs:572518
UUID:
uuid:f8391bf0-e2c0-47ca-a185-09ee03068211
Local pid:
pubs:572518
Source identifiers:
572518
Deposit date:
2016-02-19

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