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Journal article

Application of single-cell genomics in cancer: promise and challenges.

Abstract:

Recent advances in single-cell genomics are opening up unprecedented opportunities to transform cancer genomics. While bulk tissue genomic analysis across large populations of tumour cells has provided key insights into cancer biology, this approach does not provide the resolution that is critical for understanding the interaction between different genetic events within the cellular hierarchy of the tumour during disease initiation, evolution, relapse and metastasis. Single-cell genomic appro...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/hmg/ddv235

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, WIMM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
24
Issue:
R1
Pages:
R74-R84
Publication date:
2015-06-25
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:f8391bf0-e2c0-47ca-a185-09ee03068211
Source identifiers:
572518
Local pid:
pubs:572518
Language:
English

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