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Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

Abstract:

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals who were chronically infected with HCV, predominantly genotype 3. We show that both alleles of genes encoding human leukocyte antigen molecules and genes encoding components of the interferon lambda innate immune system drive ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ng.3835

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Department:
Wadham College
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Von Delft, A More by this author
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Funding agency for:
Ansari, M
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Funding agency for:
McVean, G
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Funding agency for:
McLauchlan, J
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Funding agency for:
McLauchlan, J
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Issue:
5
Pages:
653-814
Publication date:
2017-04-10
Acceptance date:
2017-03-10
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:689216
URN:
uri:f82608ed-7142-4e4c-9d07-789b16d72c09
UUID:
uuid:f82608ed-7142-4e4c-9d07-789b16d72c09
Local pid:
pubs:689216
Language:
English
Keywords:

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