- Abstract:
-
This review summarizes advances in our understanding of the structure and function of the ATP-sensitive potassium (K(ATP)) channel of the pancreatic beta-cell that have been made over the last 5 years. It discusses recent structural studies of the octameric K(ATP) channel complex and studies of the regulation of K(ATP) channel activity by nucleotides. It then considers the molecular mechanism by which gain-of-function mutations in the Kir6.2 subunit of the K(ATP) channel reduce channel inhibi...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1042/bst20060243
-
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- Journal:
- Biochemical Society transactions
- Volume:
- 34
- Issue:
- Pt 2
- Pages:
- 243-246
- Publication date:
- 2006-04-05
- DOI:
- EISSN:
-
1470-8752
- ISSN:
-
0300-5127
- URN:
-
uuid:f820e968-73dc-484d-8387-1d516dbffe2b
- Source identifiers:
-
113695
- Local pid:
- pubs:113695
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
K(ATP) channels and insulin secretion: a key role in health and disease.
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