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K(ATP) channels and insulin secretion: a key role in health and disease.

Abstract:

This review summarizes advances in our understanding of the structure and function of the ATP-sensitive potassium (K(ATP)) channel of the pancreatic beta-cell that have been made over the last 5 years. It discusses recent structural studies of the octameric K(ATP) channel complex and studies of the regulation of K(ATP) channel activity by nucleotides. It then considers the molecular mechanism by which gain-of-function mutations in the Kir6.2 subunit of the K(ATP) channel reduce channel inhibi...

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Publication status:
Published

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Publisher copy:
10.1042/bst20060243

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Biochemical Society transactions
Volume:
34
Issue:
Pt 2
Pages:
243-246
Publication date:
2006-04-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:f820e968-73dc-484d-8387-1d516dbffe2b
Source identifiers:
113695
Local pid:
pubs:113695

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