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Finasteride to prevent prostate cancer: should all men or only a high-risk subgroup be treated?

Abstract:

PURPOSE Finasteride has been shown to reduce the incidence of prostate cancer. Yet the use of finasteride remains low, likely because of the risk of adverse effects. We sought to determine whether prostate-specific antigen (PSA) levels could identify a high-risk subgroup for which the benefits of finasteride treatment outweigh the potential harms. PATIENTS AND METHODS Raw data from the Prostate Cancer Prevention Trial were used to model chemopreventive treatment strategies: treat all men, tre...

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Publisher copy:
10.1200/jco.2009.23.5572

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume:
28
Issue:
7
Pages:
1112-1116
Publication date:
2010-03-05
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
URN:
uuid:f8173e97-8ceb-428e-a5a5-d5fceb7806be
Source identifiers:
365905
Local pid:
pubs:365905

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