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Erf affects commitment and differentiation of osteoprogenitor cells in cranial sutures via the retinoic acid pathway

Abstract:

ETS2 repressor factor (ERF) haploinsufficiency causes late onset craniosynostosis (OMIM 600775; CRS4) in humans while in mice Erf-insufficiency also leads to a similar multi-suture synostosis phenotype preceded by mildly reduced calvarium ossification. However, neither the cell types affected nor the effects per se have been identified so far. Here we establish an ex vivo system for the expansion of suture-derived mesenchymal stem and progenitor cells (sdMSCs) and analyze the role of Erf leve...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/MCB.00149-21

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MSD
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MSD
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MSD
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Publisher:
American Society for Microbiology
Journal:
Molecular and Cellular Biology More from this journal
Volume:
41
Issue:
8
Article number:
e00149-21
Publication date:
2021-05-10
Acceptance date:
2021-04-29
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Language:
English
Keywords:
Pubs id:
1174001
Local pid:
pubs:1174001
Deposit date:
2021-04-30

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