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A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

Abstract:

Medullary thymic epithelial cells (mTECs) are critical in establishing and maintaining the appropriate microenvironment for negative selection and maturation of immunocompetent T cells with a self-tolerant T cell antigen receptor repertoire. Cues that direct proliferation and maturation of mTECs are provided by members of the tumor necrosis factor (TNF) superfamily expressed on developing thymocytes. Here we demonstrate a negative role of the morphogen TGF-β in tempering these signals under p...

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Publisher copy:
10.1038/ni.2869
Publisher:
Nature Publishing Group
Journal:
Nature Immunology More from this journal
Volume:
15
Issue:
6
Pages:
554-561
Publication date:
2014-01-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Language:
English
Pubs id:
pubs:470271
UUID:
uuid:f8074c72-4e5a-4737-bf0f-fde3b605a5eb
Local pid:
pubs:470271
Source identifiers:
470271
Deposit date:
2014-10-07

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