- Abstract:
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Many long non-coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar, a CNS-expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome-wide manner. We show here that the Paupar lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared targe...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 4.7MB)
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- Publisher copy:
- 10.15252/embj.201798219
-
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- Publisher:
- EMBO Press Publisher's website
- Journal:
- EMBO Journal Journal website
- Pages:
- e98219
- Publication date:
- 2018-04-16
- Acceptance date:
- 2018-03-08
- DOI:
- EISSN:
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1460-2075
- ISSN:
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0261-4189
- Pubs id:
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pubs:840607
- URN:
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uri:f7f6d418-6e5e-4d40-a785-8770e56d2aea
- UUID:
-
uuid:f7f6d418-6e5e-4d40-a785-8770e56d2aea
- Local pid:
- pubs:840607
- Language:
- English
- Keywords:
- Copyright holder:
- Woodcock et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published under the terms of the CC BY 4.0. This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. license
Journal article
The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis
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