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The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis

Abstract:

Many long non-coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar, a CNS-expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome-wide manner. We show here that the Paupar lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared targe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/embj.201798219

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Role:
Author
ORCID:
0000-0003-2514-0977
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Pages:
e98219
Publication date:
2018-04-16
Acceptance date:
2018-03-08
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:840607
URN:
uri:f7f6d418-6e5e-4d40-a785-8770e56d2aea
UUID:
uuid:f7f6d418-6e5e-4d40-a785-8770e56d2aea
Local pid:
pubs:840607
Language:
English
Keywords:

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