Journal article icon

Journal article

Balancing force field protein-lipid interactions to capture transmembrane helix-helix association

Abstract:

Atomistic simulations have recently been shown to be sufficiently accurate to reversibly fold globular proteins and have provided insights into folding mechanisms. Gaining similar understanding from simulations of membrane protein folding and association would be of great medical interest. All-atom simulations of the folding and assembly of transmembrane protein domains are much more challenging, not least due to very slow diffusion within the lipid bilayer membrane. Here, we focus on a simpl...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1021/acs.jctc.7b00983

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Christ Church
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
National Institutes of Health More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Chemical Theory and Computation Journal website
Volume:
14
Issue:
3
Pages:
1706–1715
Publication date:
2018-02-09
Acceptance date:
2018-01-22
DOI:
EISSN:
1549-9626
ISSN:
1549-9618
Pubs id:
pubs:821007
URN:
uri:f7f3e765-a817-4565-b228-7b47b42c5470
UUID:
uuid:f7f3e765-a817-4565-b228-7b47b42c5470
Local pid:
pubs:821007

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP