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Using a human challenge model of infection to measure vaccine efficacy: a randomised, controlled trial comparing the typhoid vaccines M01ZH09 with placebo and Ty21a

Abstract:

BACKGROUND: Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious vaccines is complicated by the human host-restriction of Salmonella enterica serovar Typhi (S. Typhi) and lack of clear correlates of protection. In this study, we aimed to evaluate the protective efficacy of a single dose of the oral ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pntd.0004926

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Department:
Oxford, MSD, Paediatrics
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Department:
Oxford, MSD, Paediatrics
More by this author
Department:
Oxford, MSD, Paediatrics
More by this author
Department:
Oxford, MSD, Paediatrics
More by this author
Department:
Oxford, MSD, Paediatrics
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Funding agency for:
Pollard, Andrew
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Grant:
Strategic Translational Award (grant number 092661 to AJP)
Emergent BioSolutions More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
10
Issue:
8
Pages:
e0004926
Publication date:
2016-08-05
DOI:
ISSN:
1935-2735
Pubs id:
pubs:639007
URN:
uri:f7efda85-ee14-4a20-82b4-7744b6af392c
UUID:
f7efda85-ee14-4a20-82b4-7744b6af392c
Local pid:
pubs:639007
Paper number:
8
Language:
English
Keywords:

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