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Using a human challenge model of infection to measure vaccine efficacy: a randomised, controlled trial comparing the typhoid vaccines M01ZH09 with placebo and Ty21a

Abstract:

BACKGROUND: Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious vaccines is complicated by the human host-restriction of Salmonella enterica serovar Typhi (S. Typhi) and lack of clear correlates of protection. In this study, we aimed to evaluate the protective efficacy of a single dose of the oral ...

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Publication status:
Published
Peer review status:
Peer reviewed

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  • (Version of record, pdf, 4.3MB)
Publisher copy:
10.1371/journal.pntd.0004926

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Pollard, A
Grant:
Strategic Translational Award (092661
Strategic Translational Award (grant number 092661 to AJP
Publisher:
Public Library of Science
Journal:
PLoS Neglected Tropical Diseases More from this journal
Volume:
10
Issue:
8
Pages:
e0004926
Publication date:
2016-08-01
Acceptance date:
2016-07-25
DOI:
ISSN:
1935-2735
Language:
English
Keywords:
Pubs id:
pubs:639007
UUID:
uuid:f7efda85-ee14-4a20-82b4-7744b6af392c
Local pid:
pubs:639007
Source identifiers:
639007
Deposit date:
2016-08-18

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