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Novel antibiotic-loaded particles conferring eradication of deep tissue bacterial reservoirs for the treatment of chronic urinary tract infection

Abstract:

A significant proportion of urinary tract infection (UTI) patients experience recurrent episodes, due to deep tissue infection and treatment-resistant bacterial reservoirs. Direct bladder instillation of antibiotics has proved disappointing in treating UTI, likely due to the failure of infused antibiotics to penetrate the bladder epithelium and accumulate to high enough levels to kill intracellular bacteria. This work investigates the use of nitrofurantoin loaded poly(lactic-co-glycolic acid)...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1016/j.jconrel.2020.08.048

Authors


Publisher:
Elsevier
Journal:
Journal of Controlled Release More from this journal
Volume:
328
Pages:
490-502
Publication date:
2020-09-01
Acceptance date:
2020-08-24
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
Pmid:
32882271
Language:
English
Keywords:
Pubs id:
1131820
Local pid:
pubs:1131820
Deposit date:
2020-11-04

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