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Journal article

Tumour gene expression signature in primary melanoma predicts long-term outcomes

Abstract:

Adjuvant systemic therapies are now routinely used following resection of stage III melanoma, however accurate prognostic information is needed to better stratify patients. We use differential expression analyses of primary tumours from 204 RNA-sequenced melanomas within a large adjuvant trial, identifying a 121 metastasis-associated gene signature. This signature strongly associated with progression-free (HR = 1.63, p = 5.24 × 10−5) and overall survival (HR = 1.61, p = 1.67 × 10−4), was vali...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-21207-2

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Name:
European Union’s Horizon 2020 research and innovation programme
Publisher:
Springer Nature
Journal:
Nature More from this journal
Volume:
12
Article number:
1137
Publication date:
2021-02-18
Acceptance date:
2021-01-15
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
Pubs id:
1157855
Local pid:
pubs:1157855
Deposit date:
2021-01-22

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