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A COVID moonshot: assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological cause of the coronavirus disease 2019, for which no efective antiviral therapeutics are available. The SARS-CoV-2 main protease (Mpro) is essential for viral replication and constitutes a promising therapeutic target. Many eforts aimed at deriving efective Mpro inhibitors are currently underway, including an international open-science discovery project, codenamed COVID Moonshot. As part of COVID Moonshot, we used ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s10858-021-00365-x

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-0671-2207
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Springer Nature
Journal:
Journal of Biomolecular NMR More from this journal
Volume:
75
Issue:
2021
Pages:
167–178
Publication date:
2021-04-15
Acceptance date:
2021-03-23
DOI:
EISSN:
1573-5001
ISSN:
0925-2738
Language:
English
Keywords:
Pubs id:
1169709
Local pid:
pubs:1169709
Deposit date:
2021-03-30

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