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Journal article

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.

Abstract:

Objectives

To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age.

Design

Analysis of genotype, PCa status, and age to select single nucleotide polymorphisms (SNPs) associated with diagnosis. These polymorphisms were incorporated into a survival analysis to estimate their effects on age at diagnosis of aggressive PCa (that is, not eligible for surveillance according...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmj.j5757

Authors


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Name:
National Institute for Health Research
Grant:
NF-SI-0513-10121
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Name:
South East Norway Health Authority
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Name:
Research Council of Norway
More from this funder
Name:
Prostate Cancer Foundation
Publisher:
BMJ Publishing Group
Journal:
BMJ More from this journal
Volume:
360
Pages:
j5757
Publication date:
2018-01-01
Acceptance date:
2017-12-04
DOI:
EISSN:
1756-1833
ISSN:
1756-1833
Pmid:
29321194
Language:
English
Keywords:
Pubs id:
pubs:819421
UUID:
uuid:f7b9624b-991e-456c-bc75-3f4103948d19
Local pid:
pubs:819421
Source identifiers:
819421
Deposit date:
2018-01-14

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