Journal article icon

Journal article

HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities

Abstract:

Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E homolog)-restricted T cell responses that mediated post-challenge SIV replication arrest in >50% of animals. However, HIV-1-specific, HLA-E-restricted T cells have not been observed in HIV-1-infe...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1126/sciimmunol.abg1703

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0003-4451-6765
More by this author
Role:
Author
ORCID:
0000-0001-5732-9972
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-0587-7560
More by this author
Role:
Author
ORCID:
0000-0001-8492-5614
Publisher:
American Association for the Advancement of Science
Journal:
Science Immunology More from this journal
Volume:
6
Issue:
57
Article number:
eabg1703
Publication date:
2021-03-25
Acceptance date:
2021-02-18
DOI:
EISSN:
2470-9468
Language:
English
Keywords:
Pubs id:
1169865
Local pid:
pubs:1169865
Deposit date:
2021-04-02

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP