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Journal article

Mechanistic modeling of primaquine pharmacokinetics, gametocytocidal activity, and mosquito infectivity

Abstract:

Clinical studies have shown that adding a single 0.25 mg base/kg dose of primaquine to standard antimalarial regimens rapidly sterilizes Plasmodium falciparum gametocytes. However, the mechanism of action and overall impact on malaria transmission is still unknown. Using data from 81 adult Malians with P. falciparum falciparum gametocytemia who received the standard dihydroartemisinin-piperaquine treatment course and were randomized to receive either a single dose of prim...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cpt.2512

Authors


More by this author
Institution:
University of Oxford
Department:
External
Role:
Author
ORCID:
0000-0003-3839-9777
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-1897-1978
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-4566-4030
et al.
More from this funder
Name:
Wellcome Trust
Grant:
093956/Z/10/Z
Publisher:
Wiley
Journal:
Clinical Pharmacology and Therapeutics More from this journal
Volume:
111
Issue:
3
Pages:
676-685
Publication date:
2022-01-22
Acceptance date:
2021-12-08
DOI:
EISSN:
1532-6535
ISSN:
0009-9236
Pmid:
34905220
Language:
English
Keywords:
Pubs id:
1230706
Local pid:
pubs:1230706
Deposit date:
2022-11-08

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