Journal article icon

Journal article : Review

Getting under the skin of Polycomb-dependent gene regulation

Abstract:

The Polycomb repressive system functions through chromatin to regulate gene expression and development. In this issue of Genes & Development, Cohen and colleagues (pp. 354-366) use the developing mouse epidermis as a model system to show that the two central Polycomb repressive complexes, PRC1 and PRC2, have autonomous yet overlapping functions in repressing Polycomb target genes. They show that this cooperation enables the stable repression of nonepidermal transcription factors that woul...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1101/gad.348257.121

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-8726-7888
Publisher:
Cold Spring Harbor Laboratory Press
Journal:
Genes and Development More from this journal
Volume:
35
Issue:
5-6
Pages:
301-303
Publication date:
2021-03-01
Acceptance date:
2021-01-14
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Pmid:
33649160
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1168013
Local pid:
pubs:1168013
Deposit date:
2021-03-30

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP