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Thesis

Serine hydrolase activity and roles for monoacylglycerol lipase in innate immunity and intestinal inflammation

Abstract:

Detection of evolutionarily conserved pathogen motifs by pattern recognition receptors (PRRs), particularly on dendritic cells (DCs), is crucial for adequate immune responses. Defects in DC function are known to be associated with inflammatory bowel disease (IBD). The endocannabinoid system (ECS) is the system through which exocannabinoids such as Δ9-tetrahydrocannabinol and cannabidiol signal. Regarding inflammation, cannabinoids generally exert anti-inflammatory effects, inclu...

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Division:
MSD
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:f7a12796-ae8f-4121-ab1a-26778261ac78
Deposit date:
2018-09-07

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