Journal article icon

Journal article

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

Abstract:

Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Des...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1038/s41467-024-50297-x

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-1270-6495
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-9802-8241
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
15
Issue:
1
Article number:
6265
Publication date:
2024-07-24
Acceptance date:
2024-07-04
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Language:
English
Pubs id:
2013488
Local pid:
pubs:2013488
Source identifiers:
2137519
Deposit date:
2024-07-25

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP